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present that genetic inactivation of Phd1 or Phd2 hinders progression of AML and compromises leukemic stem cells. They produce a selective PHD inhibitor IOX5 and display therapeutic efficacy in AML, that may be potentiated with venetoclax.

Applying details acquired from NCI-MATCH, three far more precision drugs trials—referred to as ComboMATCH, MyeloMATCH, and iMATCH—will examination regardless of whether drug combos can conquer resistance to cure, evaluate new therapies for myeloid leukemia and myelodysplastic syndrome, and study immune profiles and tumor markers for responsiveness to immunotherapy, respectively.

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